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Multi-mode
Separations using ZirChrom Phases
 The
basic crystalline structure of zirconia lends it unparalleled chemical and
thermal stability. The result of this unique configuration is a particle
with superior pH (1-14) and temperature (up to 200ºC)
stability. This structure also enables a unique surface chemistry.
The surface of zirconia has highly reproducible Lewis acid, Bronsted base, and
Bronsted acid sites. Although the benefits of zirconia's unparalleled
stability are clearly apparent, the more subtle value of the multi-modal nature
of zirconia may in fact be the most important factor when considering a zirconia
column for your application. The following links and application notes
detail the unique selectivity of ZirChrom phases.
MULTI-MODE
SEPARATION LINKS:
Multi-Mode
Separations on Zirconia-based Phases (PDF) -
(626K) E-Newsletter
Vol 13 - “Multi-mode
Separations and Unique Selectivity Using ZirChrom HPLC Phases”, Nov. 2008
E-Newsletter
Vol 14 - “Multi-modal
Separations Case Study: Separation of Positional Aromatic Amine Isomers using
Sub-2mm
ZirChrom®-PBD”, Nov. 2009
Ion-Exchange
Separations on Zirconia-based Stationary Phases (PDF) - (702K)
MULTI-MODE
APPLICATION NOTES: 
MODES: RP & CATION EXCHANGE
| PDF |
Column(s) |
Compound
Class |
Details |
| 174 |
PBD |
Basic Compounds |
Tri-fold PBD vs Waters |
| 294 |
PBD |
Wood Preservatives |
Tebuconazole, Propiconazole |
| 296 |
MS |
Antidepressants |
Methapyrilene, Doxepin, Brompheniramine,
Amitriptyline, Nortryptyline |
| 298 |
MS |
Beta-Blockers |
Lidocaine, Atenolol, Metoprolol, Oxprenolol,
Alprenolol |
| 299 |
MS |
Basic Pharmaceuticals |
Methapyrilene, Pyrilamine, Tripelennamine,
Brompheniramine, Desipramine, Nortryptyline, Doxepin, Amitryptyline |
| 300 |
PBD |
Basic Pharmaceuticals |
Fentanyl, Norfentanyl |
| 301 |
PBD |
Basic Pharmaceuticals |
Carfentanil, Naltrexone |
| 302 |
PBD |
Basic Pharmaceuticals |
STI-571, N-Desmethyl-STI |
| 303 |
MS |
Basic Pharmaceuticals |
Methapyrilene, Pyrilamine, Tripeleneamine,
Chlorpheniramine, Brompheniramine, Thiothixene, Doxepin,
Amitryptyline, Desipramine, Nortryptyline, Pyridine, Imipramine,
Lidocaine, Atenolol, Metoprolol, Oxprenolol, Alprenolol; Column
Comparison vs. C18 Using Neutral pH Conditions |
MODES: RP & ANION EXCHANGE
| PDF |
Column(s) |
Compound
Class |
Details |
| 166 |
SAX |
Oligonucleotides |
Poly (A)-hydrolysate |
| 267 |
SAX |
Oligonucleotides |
Poly-G Hydrolysate |
| 278 |
SAX |
Food/Cosmetics |
Measuring Caffeine, Aspartame and Benzoate in
Diet Coke, Diet Root Beer, Diet Pepsi, Diet 7-Up, Diet Sprite, Diet
Mountain Dew, Pepsi One, Diet Dr. Pepper |
| 307 |
SAX |
NSAIDs |
Acetaminophen, Ibuprofen, Naproxen, Impurity,
Ketoprofen |
| 320 |
SAX |
Glyphosate |
Isopropylamine, Glyphosate, peak D isomers, peak
C Impurity |
MODES: RP & CONFORMATIONAL SELECTIVITY
| PDF |
Column(s) |
Compound
Class |
Details |
| 134 |
CARB |
Isomers |
Ethylbenzene, m-Xylene, p-Xylene, O-Xylene |
| 232 |
PBD, CARB, DB-C18 |
Isomers |
Ethylbenzene, p-Xylene |
| 266 |
CARB |
Steroids/structurally similar |
Dihydroestradiol Sulfate, Dihydroequilin Sulfate,
Equilin Sulfate, Estrone Sulfate, Equilenin Sulfate,
Dihydroequilenin Sulfate |
| 280 |
CARB |
Nitroaromatics |
RDX, HMX, Nitrobenzene, 2-Nitrotoluene, Tetryl,
2,6-Dinitrotoluene, 4-Nitrotoluene, 1,3-Dinitrobenzene,
2,4-Dinitrotoluene, 2-amino 4,6-dinitrotoluene,
1,3,5-Trinitrobenzene |
| 279 |
DB-C18 |
Food/Cosmetics |
Nitrosamines |
| 281 |
CARB |
Monomer |
Acrylamide, Acrylic Acid |
| 295 |
DB-C18 |
Food/Cosmetics |
N-nitrosamines |
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