ZAPPS Volume 15:  

Unique Properties of ZirChrom®-PBD for Difficult Separations: Anti-Parasitic Pharmaceuticals, Triazine Herbicides, and Wood Preservatives

In this special EAS edition of Z-APPS we have included three new application notes that feature separations on the ZirChrom®-PBD phase.  This research explores how the unique selectivity and stability of ZirChrom phases can be employed to meet the toughest separation challenges.

ZirChrom will be exhibiting at the upcoming Eastern Analytical Symposium (EAS).   To learn more about this cutting edge research visit us at our EAS booth #205 on November 14-16th, 2016.

Separation of Benzimidazoles and Derivatives in Anti-parasitic drugs on ZirChrom®-PBD - Benzimidazoles are a large class of pharmaceuticals used in animal production with a broad spectrum of activity against roundworms (nematodes).1 The longer half-life of oxfendazole and fenbendazole, due to their slow metabolization, allows these compounds to be more effective but also raises the concern of residues in the final food products. Here we present a gradient separation of six closely related anti-parasitic pharmaceuticals using a ZirChrom®-PBD phase with UV detection at 254 nm.   (PDF - Full Application Note)

Fast Separation of Wood Preservatives on ZirChrom®-PBD - Overlapping phenolic compounds complicate the analysis of the preservatives tebuconazole and propiconazole in wood extract samples. A mobile phase chosen to take advantage of the multi-mode separation capability of ZirChrom®-PBD speeds and simplifies this separation. Tebuconazole and propiconazole standards were separated isocratically in under 4 minutes on a ZirChrom®-PBD column using a mobile phase optimized to separate the two preservatives while preventing the interference of phenolic compounds also present in real world samples.   (PDF - Full Application Note)

Fast Separation of Ten Triazine Herbicides on ZirChrom®-PBD - Historically, the preferred analysis method for triazines, like many herbicides, has been gas chromatography. Although HPLC techniques are non destructive, allow for large volume injections (on column enrichment), and allow the use of a wide range of detectors, their use in this application has been hindered by long run times necessary to achieve the desired resolution.  Here we present a new HPLC method that exploits the unique selectivity and thermal stability of the ZirChrom®-PBD column to separate ten triazine herbicides in less than three minutes, four times faster than the previous method, with a LC-MS compatible mobile phase  (PDF - Full Application Note)

Join Us! - ZirChrom Separations will be exhibiting at EAS 2016 on November 14th through November 16th.  ZirChrom technical experts will be staffing the ZirChrom booth, booth #205, and would be happy to assist with your most difficult separations.

To place an order for our products, or for more information, please contact us at 1-866-STABLE-1 or support@zirchrom.com .

 

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