ZirChrom®-Chiral
HPLC Columns
| ZirChrom
Separations, Inc. is pleased to announce the arrival of a full line of
zirconia-based chiral HPLC phases, ZirChrom®-Chiral. These
new patent-pending chiral stationary phases incorporate the
unsurpassed chemical and mechanical stability of zirconia with the
flexibility of Lewis acid/base anchored chiral selectors. This
combination creates a CSP that is reproducible, durable and can be
regenerated. |
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ZirChrom®-Chiral(S)LEU
CSP (Part# ZRC01) Selectivity Comparisons
Conditions:
99/1 hexane/isopropanol (all runs); 100 × 4.6 mm i.d. (part#
ZRC01-1046); flow = 1.0 mL/min; 30 °C.
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ZirChrom-Chiral
Press Release
E-Newsletter
Vol 11 - “ZirChrom-Chiral:
Zirconia-based Chiral Stationary Phases”
ZirChrom-Chiral
Application Notes
ZirChrom-Chiral
MSDS (PDF)
ZirChrom®-Chiral
columns were compared to silica columns having analogous chiral selectors
and found to have similar resolving power for the selected probe
enantiomers. Most importantly, the chemisorbed chiral selectors on
ZirChrom®-Chiral were found to be stable enough for extended
routine use; however, they could be completely removed by washing with a
high pH (>pH 12) aqueous solution and could be easily regenerated.
Currently, ZirChrom
offers five different chiral columns in the ZirChrom®-Chiral
line:
- ZirChrom®-Chiral(S)LEU
(Chiral Selector (CS): (S)-3,5-dinitrobenzoyl-leucine) Part# ZRC01
- ZirChrom®-Chiral(R)NESA
(CS: (R)-N-[1-(1-naphthyl)ethyl]succinamic acid) Part# ZRC02
- ZirChrom®-Chiral(S)NESA
(CS: (S)-N-[1-(1-naphthyl)ethyl]succinamic acid) Part# ZRC03
- ZirChrom®-Chiral(S)PG
(CS: (S)-3,5-dinitrobenzoyl-phenylglycine) Part# ZRC04
- ZirChrom®-Chiral(R)PG
(CS: (R)-3,5-dinitrobenzoyl-phenylglycine) Part# ZRC05
- ZirChrom®-CelluloZe
(CS: anchor modified
3,5-dimethylphenyl-carbamoyl cellulose) Part# ZRC06
Product development
is underway for a single, highly stable zirconia column plus a kit of pure
CSP coating reagents that will allow users to easily remove and replace
chiral selectors by reproducible and simple methods. Chiral selectors with
multiple chiral centers, featuring both pi-donor and acceptor groups, are
also under development, as are chiral selectors based on polysaccharides.
ZirChrom®-Chiral
stationary phases are available in packed columns with a growing variety
of chiral selectors.
To place an order, or for more
information or copies of our Technical Application Notes, please contact us at 1-866-STABLE-1.
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