Multi-mode Separations using ZirChrom Phases

The basic crystalline structure of zirconia lends it unparalleled chemical and thermal stability.  The result of this unique configuration is a particle with superior pH (1-14) and temperature (up to 200ºC) stability.  This structure also enables a unique surface chemistry.  The surface of zirconia has highly reproducible Lewis acid, Bronsted base, and Bronsted acid sites.  Although the benefits of zirconia's unparalleled stability are clearly apparent, the more subtle value of the multi-modal nature of zirconia may in fact be the most important factor when considering a zirconia column for your application.  The following links and application notes detail the unique selectivity of ZirChrom phases. 

MULTI-MODE SEPARATION LINKS:

Multi-Mode Separations on Zirconia-based Phases (PDF) - (626K)

E-Newsletter Vol 13 - “Multi-mode Separations and Unique Selectivity Using ZirChrom HPLC Phases”, Nov. 2008  

E-Newsletter Vol 14 - “Multi-modal Separations Case Study: Separation of Positional Aromatic Amine Isomers using Sub-2mm ZirChrom®-PBD”, Nov. 2009  

Ion-Exchange Separations on Zirconia-based Stationary Phases (PDF) - (702K)

MULTI-MODE APPLICATION NOTES:

MODES: RP & CATION EXCHANGE
PDF Column(s) Compound Class Details
174 PBD Basic Compounds Tri-fold PBD vs Waters
294 PBD Wood Preservatives Tebuconazole, Propiconazole
296 MS Antidepressants Methapyrilene, Doxepin, Brompheniramine, Amitriptyline, Nortryptyline
298 MS Beta-Blockers Lidocaine, Atenolol, Metoprolol, Oxprenolol, Alprenolol
299 MS Basic Pharmaceuticals Methapyrilene, Pyrilamine, Tripelennamine, Brompheniramine, Desipramine, Nortryptyline, Doxepin, Amitryptyline
300 PBD Basic Pharmaceuticals Fentanyl, Norfentanyl
301 PBD Basic Pharmaceuticals Carfentanil, Naltrexone
302 PBD Basic Pharmaceuticals STI-571, N-Desmethyl-STI
303 MS Basic Pharmaceuticals Methapyrilene, Pyrilamine, Tripeleneamine, Chlorpheniramine, Brompheniramine, Thiothixene, Doxepin, Amitryptyline, Desipramine, Nortryptyline, Pyridine, Imipramine, Lidocaine, Atenolol, Metoprolol, Oxprenolol, Alprenolol; Column Comparison vs. C18 Using Neutral pH Conditions

MODES: RP & ANION EXCHANGE
PDF Column(s) Compound Class Details
166 SAX Oligonucleotides Poly (A)-hydrolysate
267 SAX Oligonucleotides Poly-G Hydrolysate
278 SAX Food/Cosmetics Measuring Caffeine, Aspartame and Benzoate in Diet Coke, Diet Root Beer, Diet Pepsi, Diet 7-Up, Diet Sprite, Diet Mountain Dew, Pepsi One, Diet Dr. Pepper
307 SAX NSAIDs Acetaminophen, Ibuprofen, Naproxen, Impurity, Ketoprofen
320 SAX Glyphosate Isopropylamine, Glyphosate, peak D isomers, peak C Impurity

MODES: RP & CONFORMATIONAL SELECTIVITY
PDF Column(s) Compound Class Details
134 CARB Isomers Ethylbenzene, m-Xylene, p-Xylene, O-Xylene
232 PBD, CARB, DB-C18 Isomers Ethylbenzene, p-Xylene
266 CARB Steroids/structurally similar Dihydroestradiol Sulfate, Dihydroequilin Sulfate, Equilin Sulfate, Estrone Sulfate, Equilenin Sulfate, Dihydroequilenin Sulfate
280 CARB Nitroaromatics RDX, HMX, Nitrobenzene, 2-Nitrotoluene, Tetryl, 2,6-Dinitrotoluene, 4-Nitrotoluene, 1,3-Dinitrobenzene, 2,4-Dinitrotoluene, 2-amino 4,6-dinitrotoluene,  1,3,5-Trinitrobenzene
279 DB-C18 Food/Cosmetics Nitrosamines
281 CARB Monomer Acrylamide, Acrylic Acid
295 DB-C18 Food/Cosmetics N-nitrosamines

 

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